Sophomore forward Destiny Washington tied a career high with 25 points and junior guard Carmen Grande dished out 13 assists to help the Cardinals pull away from the Lady Governors.
Ball State only trailed one, 3-2 in the opening minutes, and went on a 12-0 run late in the first half to take a commanding 44-22 lead into the break.
The Cardinals didn't slow down in the second half either, opening with a 11-3 run to take a 30 point lead less than three minutes into the third quarter.
Sophomore guard Jasmin Samz added 18 points and Grande scored 15 to record her fourth double-double of the season. Senior forward Moriah Monaco also tallied in double figures for the Cardinals.
Sophomore guard Nieja Crawford led Austin Peay with 11 points in 19 minutes.
Next up, Ball State finishes off non-conference play when it hosts Western Kentucky on Thursday at 7 p.m. The Lady Toppers feature a win over a ranked Missouri team and close road loss to Indiana.