The win also advanced the Cardinals to the second round of the CollegeInsider.com Tournament.
Tennessee State kicked off the game with a 20-3 run. Ball State didn't gain its first lead in the game until freshman forward Trey Moses hit a 3-point shot with 5:57 remaining in the second half.
Moses recorded 13 points and 13 rebounds in the game, his first career double-double.
Sophomore guard Jeremie Tyler led the Cardinals with a career-high 25 points on 9-14 shooting. He also knocked down five 3-point baskets in nine attempts. Junior forward Ryan Weber was second on the team with 20 points.
Ball State trailed at halftime, 27-14, after hitting just 16.7 percent of its 3-point attempts (3-18). The Cardinals, however, outscored the Tigers in the second half, 38-25, in part because they hit seven of their 11 3-point attempts (63.6 percent).
Ball State's second-half turnaround left the game tied at the end of regulation, 52-52. Both teams scored 12 points in overtime, forcing a second overtime period.
The Cardinals outscored the Tigers, 14-9, in the second overtime period to secure the victory.
Though Ball State will advance to the second round, the CIT has no set bracket. The second-round pairings will be announced after the remainder of the first-round games are played on March 16.